Product Name :
MRTX1133
Description:
MRTX1133 is a potent and selective KRAS G12D inhibitor. MRTX1133 targets the KRAS G12D protein in both active and inactive states. In preclinical studies, MRTX1133 exhibited a long half-life, an ability to bind the KRAS G12D protein in both active and inactive states, and selective inhibition of KRAS G12D mutant cancer cells. In G12D mutant tumor models, MRTX1133 showed dose-dependent selective inhibition of the KRAS pathway and tumor regression.
CAS:
2621928-55-8
Molecular Weight:
600.63
Formula:
C33H31F3N6O2
Chemical Name:
2-Naphthalenol
Smiles :
C#CC1=C2C(=CC(O)=CC2=CC=C1F)C1=NC=C2C(=NC(=NC2=C1F)OC[C@]12C[C@@H](F)CN1CCC2)N1CC2CCC(C1)N2
InChiKey:
SCLLZBIBSFTLIN-IFMUVJFISA-N
InChi :
InChI=1S/C33H31F3N6O2/c1-2-23-26(35)7-4-18-10-22(43)11-24(27(18)23)29-28(36)30-25(13-37-29)31(41-15-20-5-6-21(16-41)38-20)40-32(39-30)44-17-33-8-3-9-42(33)14-19(34)12-33/h1,4,7,10-11,13,19-21,38,43H,3,5-6,8-9,12,14-17H2/t19-,20?,21?,33+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Topotecan} MedChemExpress|{Topotecan} Autophagy|{Topotecan} Purity & Documentation|{Topotecan} References|{Topotecan} manufacturer|{Topotecan} Cancer}
Shelf Life:
≥12 months if stored properly.{{4-Methylumbelliferone} medchemexpress|{4-Methylumbelliferone} Purity & Documentation|{4-Methylumbelliferone} Data Sheet|{4-Methylumbelliferone} custom synthesis|{4-Methylumbelliferone} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24518703
Additional information:
MRTX1133 is a potent and selective KRAS G12D inhibitor. MRTX1133 targets the KRAS G12D protein in both active and inactive states. In preclinical studies, MRTX1133 exhibited a long half-life, an ability to bind the KRAS G12D protein in both active and inactive states, and selective inhibition of KRAS G12D mutant cancer cells. In G12D mutant tumor models, MRTX1133 showed dose-dependent selective inhibition of the KRAS pathway and tumor regression.|Product information|CAS Number: 2621928-55-8|Molecular Weight: 600.63|Formula: C33H31F3N6O2|Chemical Name: 2-Naphthalenol|Smiles: C#CC1=C2C(=CC(O)=CC2=CC=C1F)C1=NC=C2C(=NC(=NC2=C1F)OC[C@]12C[C@@H](F)CN1CCC2)N1CC2CCC(C1)N2|InChiKey: SCLLZBIBSFTLIN-IFMUVJFISA-N|InChi: InChI=1S/C33H31F3N6O2/c1-2-23-26(35)7-4-18-10-22(43)11-24(27(18)23)29-28(36)30-25(13-37-29)31(41-15-20-5-6-21(16-41)38-20)40-32(39-30)44-17-33-8-3-9-42(33)14-19(34)12-33/h1,4,7,10-11,13,19-21,38,43H,3,5-6,8-9,12,14-17H2/t19-,20?,21?,33+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|