Ssandra Durazzo 1, , Roberta Bernini 2 , Margherita Campo 3 , Chiara Vita four , Eliana B. Souto five,6 , Ginevra Lombardi-Boccia 1 , Mohamed Fawzy Sutezolid Description Ramadan 7,eight , Antonello Santini 9 and Annalisa Romani6Citation: Lucarini, M.; Durazzo, A.; Bernini, R.; Campo, M.; Vita, C.; Souto, E.B.; Lombardi-Boccia, G.; Ramadan, M.F.; Santini, A.; Romani, A. Fruit Wastes as a Important Source of Value-Added Compounds: A Collaborative Perspective. Molecules 2021, 26, 6338. https://doi.org/ 10.3390/molecules26216338 Academic Editors: Domenico Trombetta, Antonella Smeriglio and Rafal M. Lukasik Received: 19 August 2021 Accepted: 13 October 2021 Published: 20 October8CREA-Research Centre for Food and Nutrition, Through Ardeatina 546, 00178 Rome, Italy; g.lombardiboccia@crea.gov.it Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, Via San Camillo de Lellis, 01100 Viterbo, Italy; [email protected] PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement Technology and Analysis)-DiSIA, Division of Statistics, Pc Science, Applications “G. Parenti”, University of Florence, Through U. Schiff, 6-50019 Sesto Fiorentino, 50121 Florence, Italy; [email protected] (M.C.); [email protected] (A.R.) QuMAP-PIN S.c.r.l.-Polo Universitario “Cittdi Prato” Servizi didattici e scientifici per l’Universitdi Firenze, Piazza Giovanni Ciardi, 25-59100 Prato, Italy; [email protected] Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, P o das Ci cias da Sa e, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; [email protected] CEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig 44519, Egypt; [email protected] Deanship of Scientific Investigation, Umm Al-Qura University, Makkah 24231, Saudi Arabia Division of Pharmacy, University of Napoli Federico II, By means of D. Montesano 49, 80131 Napoli, Italy; [email protected] Correspondence: [email protected] (M.L.); [email protected] (A.D.)Publisher’s Note: MDPI stays neutral with regard to DMPO Formula jurisdictional claims in published maps and institutional affiliations.Abstract: The by-products/wastes from agro-food and in distinct the fruit sector represents from one particular side a problem given that they can’t be disposed as such for their impact on the environment however they will need to become treated as a waste. Even so, on the other side, they’re a source of bioactive healthier beneficial compounds which is often recovered and be the starting material for other merchandise inside the view of sustainability in addition to a circular economy addressing the global aim of “zero waste” inside the atmosphere. An updated view from the state of art of your study on fruit wastes is here provided below this point of view. The subject is defined as follows: (i) literature quantitative evaluation of fruit waste/by-products, with particular regards to linkage with wellness; (ii) an updated view of traditional and revolutionary extraction procedures; (iii) high-value added compounds obtained from fruit waste and associated biological properties; (iv) fruit wastes presence and relevance in updated databases. Currently, the investigation in the most important components and related bioactivities of fruit wastes is being continuously explored all through integrated and multidisciplinary approaches towards the exploitation of emerging fields of application which may perhaps permit to create ec.