W, China has achievedPlants 2021, ten,23 of200 tons/year production capacity, but the production is only limited to phycocyanin (https://www.binmei-global.com/about-us/ Assessed date: 28 June 2021). To get larger efficiency of growth and desired biomolecules, it can be vital to optimize relevant parameters in large-scale sensible applications and develop optimal situations on the photobioreactor [113,114]. Third, the major drawback in the use of phycobiliproteins could be the high production expense. Added screening of indigenous and novel cyanobacterial species/strains for higher content material of phycobiliproteins and fast-growing capability, helpful harvesting, and economical purification PF-05105679 supplier approaches may possibly reduce the production price of phycobiliprotein. A further important aspect of phycobiliproteins study that must be highlighted will be the taxonomy of algae species plus the classification of phycobiliproteins. The use of an “omics” (genomics, metabolomics, proteomics, and transcriptomics) method in investigation can allow the identification of species, detection of nutritional approaches, the interaction of symbiotic relationships with bacteria, as well as the biosynthesis of biomolecules, in particular secondary metabolites [24]. These topic matters can help have an understanding of the metabolic pathways and regulatory mechanisms triggering the production of phycobiliproteins [113]. Besides, the development and utilization of robust platforms (Dictionary of Natural Goods, MassBank, Worldwide Organic Products Social Molecular Networking, and AntiBase) for data exchange and understanding transfer/dissemination will undoubtedly facilitate new scientific know-how and know-how [24].Figure 12. The challenges of phycobiliproteins study and its approaches.4. Conclusions The characteristics of phycobiliprotein-related publications from 1909 to 2020 and investigation hotspots were analyzed in this study. In accordance with the findings, phycobiliproteins sparked the widespread interest of researchers. The drastic improve of phycobiliprotein investigation with regards to quantity more than the final ten decades revealed a speedy development, specifically from 2017 onwards. This can be consistent together with the development with the phycobiliprotein market place. There have been 2214 sources that published a total of 8296 publications. The majority with the publications were articles, and also a couple of reviews were interspersed amongst them. Nearly all of the publications have been written in English. The most subject location and journals that participated inside the phycobiliproteins study have been “biochemistry, genetics, and molecularPlants 2021, 10,24 ofbiology” and “Journal of Applied Phycology”, respectively. The U.S.A. and China have been the main contributors within the study of phycobiliproteins, though the U.S.A. and Germany had been strongly interwoven within a worldwide analysis network. Glazer, Alexander N. in the University of BI-425809 GlyT California, U.S.A. was the leading prolific author in phycobiliprotein investigation. All round, the worldwide collaboration network has benefited in the rapid growth of phycobiliprotein analysis. As outlined by keyword analysis trends, the scope of phycobiliprotein analysis contains the optimization of algae culture approaches and phycobiliprotein extraction processes, categorization of phycobiliproteins, phycobiliprotein biosynthesis pathway, phycobiliprotein bioactivities, and phycobiliprotein applications. One of the most commonly utilized model organisms within the phycobiliprotein study had been Arthrospira and Synechococcus. The study trend working with keyword burst detect.