Product Name :
Purpurogallin
Description:
Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 µM. Purpurogallin has antioxidant and anti-inflammatory effects.
CAS:
569-77-7
Molecular Weight:
220.18
Formula:
C11H8O5
Chemical Name:
2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one
Smiles :
OC1C=C2C=CC=C(O)C(=O)C2=C(O)C=1O
InChiKey:
WDGFFVCWBZVLCE-UHFFFAOYSA-N
InChi :
InChI=1S/C11H8O5/c12-6-3-1-2-5-4-7(13)10(15)11(16)8(5)9(6)14/h1-4,13,15-16H,(H,12,14)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 µM. Purpurogallin has antioxidant and anti-inflammatory effects.|Product information|CAS Number: 569-77-7|Molecular Weight: 220.18|Formula: C11H8O5|Chemical Name: 2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one|Smiles: OC1C=C2C=CC=C(O)C(=O)C2=C(O)C=1O|InChiKey: WDGFFVCWBZVLCE-UHFFFAOYSA-N|InChi: InChI=1S/C11H8O5/c12-6-3-1-2-5-4-7(13)10(15)11(16)8(5)9(6)14/h1-4,13,15-16H,(H,12,14)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (567.72 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Purpurogallin (50 or 100 µM; 7 or 25 hours; BV2 murine microglial cells) treatment attenuates the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells.{{Acetamiprid} site|{Acetamiprid} Neuronal Signaling|{Acetamiprid} Biological Activity|{Acetamiprid} In Vivo|{Acetamiprid} supplier|{Acetamiprid} Cancer} Purpurogallin (100 µM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells.{{Escitalopram} MedChemExpress|{Escitalopram} Neuronal Signaling|{Escitalopram} Biological Activity|{Escitalopram} Data Sheet|{Escitalopram} custom synthesis|{Escitalopram} Autophagy} |In Vivo:|Purpurogallin (100-400 μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression.PMID:23543429 |Products are for research use only. Not for human use.|