Product Name :
BiP inducer X
Description:
BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress.
CAS:
101714-41-4
Molecular Weight:
209.22
Formula:
C9H7NO3S
Chemical Name:
2-(cyanosulfanyl)-1-(3, 4-dihydroxyphenyl)ethan-1-one
Smiles :
N#CSCC(=O)C1C=C(O)C(O)=CC=1
InChiKey:
SVFLBLCWKKQKDW-UHFFFAOYSA-N
InChi :
InChI=1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3,11-12H,4H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress.|Product information|CAS Number: 101714-41-4|Molecular Weight: 209.22|Formula: C9H7NO3S|Chemical Name: 2-(cyanosulfanyl)-1-(3, 4-dihydroxyphenyl)ethan-1-one|Smiles: N#CSCC(=O)C1C=C(O)C(O)=CC=1|InChiKey: SVFLBLCWKKQKDW-UHFFFAOYSA-N|InChi: InChI=1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3,11-12H,4H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BiP inducer X (5 μM; 0-12 hours; SK-N-SH cells) increase BiP protein.{{Betamethasone} medchemexpress|{Betamethasone} Apoptosis|{Betamethasone} Purity & Documentation|{Betamethasone} Formula|{Betamethasone} manufacturer|{Betamethasone} Autophagy} The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway.{{MSAB} site|{MSAB} Stem Cell/Wnt|{MSAB} Biological Activity|{MSAB} Data Sheet|{MSAB} supplier|{MSAB} Epigenetic Reader Domain} BiP inducer X (5 μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4.PMID:23847952 |In Vivo:|BiP inducer X administration reduces the insults due to cerebral infarction. A 20 μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion.|References:|Yoo SA, et al. A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis. J Exp Med. 2012;209(4):871-886.Kudo T, et al. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008;15(2):364-375. Products are for research use only. Not for human use.|