Product Name :
Mevociclib
Description:
Mevociclib (SY-1365) is a potent and first-in-class selective CDK7 inhibitor, with a Ki of 17.4 nM. Mevociclib exhibits anti-proliferative and apoptotic effects in solid tumor cell lines. Mevociclib possesses anti-tumor activity in hematological and multiple aggressive solid tumors.
CAS:
1816989-16-8
Molecular Weight:
587.12
Formula:
C31H35ClN8O2
Chemical Name:
N-[(1S,3R)-3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-1-methylcyclohexyl]-5-[(2E)-4-(dimethylamino)but-2-enamido]pyridine-2-carboxamide
Smiles :
CN(C)C/C=C/C(=O)NC1=CN=C(C=C1)C(=O)N[C@]1(C)C[C@@H](CCC1)NC1=NC(=C(Cl)C=N1)C1=CNC2=CC=CC=C12
InChiKey:
SCJNYBYSTCRPAO-LXBQGUBHSA-N
InChi :
InChI=1S/C31H35ClN8O2/c1-31(39-29(42)26-13-12-21(17-33-26)36-27(41)11-7-15-40(2)3)14-6-8-20(16-31)37-30-35-19-24(32)28(38-30)23-18-34-25-10-5-4-9-22(23)25/h4-5,7,9-13,17-20,34H,6,8,14-16H2,1-3H3,(H,36,41)(H,39,42)(H,35,37,38)/b11-7+/t20-,31+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Deferoxamine} MedChemExpress|{Deferoxamine} HIF/HIF Prolyl-Hydroxylase|{Deferoxamine} Purity & Documentation|{Deferoxamine} Data Sheet|{Deferoxamine} custom synthesis|{Deferoxamine} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Mevociclib (SY-1365) is a potent and first-in-class selective CDK7 inhibitor, with a Ki of 17.4 nM. Mevociclib exhibits anti-proliferative and apoptotic effects in solid tumor cell lines. Mevociclib possesses anti-tumor activity in hematological and multiple aggressive solid tumors.|Product information|CAS Number: 1816989-16-8|Molecular Weight: 587.12|Formula: C31H35ClN8O2|Chemical Name: N-[(1S,3R)-3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-1-methylcyclohexyl]-5-[(2E)-4-(dimethylamino)but-2-enamido]pyridine-2-carboxamide|Smiles: CN(C)C/C=C/C(=O)NC1=CN=C(C=C1)C(=O)N[C@]1(C)C[C@@H](CCC1)NC1=NC(=C(Cl)C=N1)C1=CNC2=CC=CC=C12|InChiKey: SCJNYBYSTCRPAO-LXBQGUBHSA-N|InChi: InChI=1S/C31H35ClN8O2/c1-31(39-29(42)26-13-12-21(17-33-26)36-27(41)11-7-15-40(2)3)14-6-8-20(16-31)37-30-35-19-24(32)28(38-30)23-18-34-25-10-5-4-9-22(23)25/h4-5,7,9-13,17-20,34H,6,8,14-16H2,1-3H3,(H,36,41)(H,39,42)(H,35,37,38)/b11-7+/t20-,31+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (212.{{SMCC} medchemexpress|{SMCC} ADC Linker|{SMCC} Technical Information|{SMCC} Purity|{SMCC} manufacturer|{SMCC} Epigenetics} 90 mM; Need ultrasonic).PMID:23357584 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Mevociclib exhibits inhibition for CDK7/CycH/MAT1 with an IC50 of 20 nM. Mevociclib is a highly selective covalent CDK7 inhibitor, induces apoptosis in leukemia cells, but not in non-malignant cells. Mevociclib exhibits activity in breast, ovarian, colorectal and lung cancer cells that exhibited low nM EC50 and rapid induction of apoptosis.|In Vivo:|Mevociclib (20mg/kg; i.v.; biw; for 35 days) inhibits tumor growth in TNBC in vivo models. Mevociclib induces unique transcriptional signature.|Products are for research use only. Not for human use.|