Product Name :
Emiglitate
Description:
Emiglitate (BAY o 1248) is a potent, selective and competitive inhibitor of α-glucoside hydrolase.
CAS:
80879-63-6
Molecular Weight:
355.38
Formula:
C17H25NO7
Chemical Name:
ethyl 4-{2-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]ethoxy}benzoate
Smiles :
CCOC(=O)C1C=CC(=CC=1)OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChiKey:
NWWORXYTJRPSMC-QKPAOTATSA-N
InChi :
InChI=1S/C17H25NO7/c1-2-24-17(23)11-3-5-12(6-4-11)25-8-7-18-9-14(20)16(22)15(21)13(18)10-19/h3-6,13-16,19-22H,2,7-10H2,1H3/t13-,14+,15-,16-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{AUDA} MedChemExpress|{AUDA} Metabolic Enzyme/Protease|{AUDA} Technical Information|{AUDA} References|{AUDA} manufacturer|{AUDA} Epigenetics}
Shelf Life:
≥12 months if stored properly.{{Piroxicam} web|{Piroxicam} COX|{Piroxicam} Purity & Documentation|{Piroxicam} In Vitro|{Piroxicam} supplier|{Piroxicam} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32180353
Additional information:
Emiglitate (BAY o 1248) is a potent, selective and competitive inhibitor of α-glucoside hydrolase.|Product information|CAS Number: 80879-63-6|Molecular Weight: 355.38|Formula: C17H25NO7|Chemical Name: ethyl 4-{2-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]ethoxy}benzoate|Smiles: CCOC(=O)C1C=CC(=CC=1)OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO|InChiKey: NWWORXYTJRPSMC-QKPAOTATSA-N|InChi: InChI=1S/C17H25NO7/c1-2-24-17(23)11-3-5-12(6-4-11)25-8-7-18-9-14(20)16(22)15(21)13(18)10-19/h3-6,13-16,19-22H,2,7-10H2,1H3/t13-,14+,15-,16-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Emiglitate greatly suppresses the glucose-stimulated insulin release in parallel with an inhibitory effect on the activities of acid glucan-1,4-α-glucosidase and acid α-glucosidase. In contrast, the activities of acid phosphatase and N-acetyl-β-D-glucosaminidase tend to increase in the presence of the α-glucoside hydrolase inhibitor. The CO-induced amplification of the glucose-stimulated insulin release as well as of the increased activities of the acid α-glucoside hydrolases are abrogated by emiglitate and displayed the same levels as in the absence of CO. The CO-induced rise in the activities of acid phosphatase and acid N-acetyl-β-D-glucosaminidase is not appreciably affected by emiglitate.|In Vivo:|In fasted rats, emiglitate inducec a significant, dose-dependent increase of hepatic glycogen concentrations. The increase in hepatic glycogen is due to lysosomal storage of glycogen only. Emiglitate in the amount of 5 mg/kg b.wt. does not induce significant changes either of glycogen concentrations or at the EM-level.|Products are for research use only. Not for human use.|